Labosky P A, Winnier G E, Sasaki H, Blessing M, Hogan B L
Howard Hughes Medical Institute, Vanderbilt University Medical School, Nashville, Tennessee, 37232-2175, USA.
Genomics. 1996 Jun 1;34(2):241-5. doi: 10.1006/geno.1996.0275.
Members of the winged helix family of transcription factors are required for the normal embryonic development of the mouse. Using the interspecific backcross panel from The Jackson Laboratory, we have determined the chromosomal locations of four genes that encode winged helix containing proteins. Mf1 was assigned to mouse Chromosome 8, Mf2 to Chromosome 4, Mf3 to Chromosome 9, and Mf4 to Chromosome 13. Since Mf3 is located in a region of Chromosome 9 containing many well-characterized mouse mutations such as short ear (se), ashen (ash), and dilute (d), we have analyzed deletion mutants to determine the location of Mf3 more precisely.
转录因子的翼状螺旋家族成员是小鼠正常胚胎发育所必需的。利用杰克逊实验室的种间回交面板，我们确定了四个编码含翼状螺旋蛋白的基因的染色体位置。Mf1定位于小鼠第8号染色体，Mf2定位于第4号染色体，Mf3定位于第9号染色体，Mf4定位于第13号染色体。由于Mf3位于第9号染色体的一个区域，该区域包含许多特征明确的小鼠突变，如短耳（se）、灰白色（ash）和稀释（d），我们分析了缺失突变体以更精确地确定Mf3的位置。
