编码小鼠细胞色素c基因的体细胞特异性和睾丸特异性同种型的基因定位于6号和2号染色体的旁系同源区域。

The genes encoding the somatic and testis-specific isotypes of the mouse cytochrome c genes map to paralogous regions of chromosomes 6 and 2.

作者信息

Hake L E, Kuemmerle N, Hecht N B, Kozak C A

机构信息

Department of Biology, Tufts University, Medford, Massachusetts 02155.

出版信息

Genomics. 1994 Apr;20(3):503-5. doi: 10.1006/geno.1994.1210.

DOI:10.1006/geno.1994.1210

PMID:8034327

Abstract

Using mouse probes specific to cytochrome cs and to cytochrome cT, the single-copy genes encoding these two proteins have been mapped to paralogous chromosomal regions by analysis of restriction fragment length variants in interspecific crosses. The gene for cytochrome cs, Cycs, maps to a position between Tcrb and Cbl-1 on proximal mouse Chromosome 6, and the gene for cytochrome cT, Cyct, maps between Gad-1 and Sfpi-1 on mouse Chromosome 2.

摘要

利用针对细胞色素cs和细胞色素cT的小鼠探针，通过分析种间杂交中的限制性片段长度变异，已将编码这两种蛋白质的单拷贝基因定位到同源染色体区域。细胞色素cs的基因Cycs定位于小鼠近端6号染色体上Tcrb和Cbl-1之间的位置，而细胞色素cT的基因Cyct定位于小鼠2号染色体上Gad-1和Sfpi-1之间。