在人类和小鼠的X染色体之间定义了一个新的保守区域。

A new region of conservation is defined between human and mouse X chromosomes.

作者信息

Dinulos M B, Bassi M T, Rugarli E I, Chapman V, Ballabio A, Disteche C M

机构信息

Department of Pathology, University of Washington, Seattle, Washington, 98195, USA.

出版信息

Genomics. 1996 Jul 1;35(1):244-7. doi: 10.1006/geno.1996.0347.

DOI:10.1006/geno.1996.0347

PMID:8661129

Abstract

Comparative mapping of the X chromosome in eutherian mammals has revealed distinct regions of conservation as well as evolutionary rearrangements between human and mouse. Recently, we and others mapped the murine homologue of CLCN4 (Chloride channel 4) to band F4 of the X chromosome in Mus spretus but to chromosome 7 in laboratory strains. We now report the mapping of the murine homologues of APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), two genes that are located on the human X chromosome at band p22. 3 and in close proximity to CLCN4. Interestingly, Oa1 and Apxl map to bands F2-F3 in both M. spretus and the laboratory strain C57BL/6J, defining a new rearrangement between human and mouse X chromosomes.

摘要

真兽亚纲哺乳动物X X X 染色体的比较图谱揭示了人类和小鼠之间保守的不同区域以及进化重排。最近，我们和其他人将 CLCN4（氯离子通道 4）的小鼠同源物定位到了家鼠 X 染色体的 F4 带，但在实验室品系中则定位到了 7 号染色体。我们现在报告了 APXL（非洲爪蟾顶端蛋白样）和 OA1（I 型眼白化病）这两个基因的小鼠同源物的定位情况，这两个基因位于人类 X 染色体的 p22.3 带，且与 CLCN4 紧邻。有趣的是，在小家鼠和实验室品系 C57BL/6J 中，Oa1 和 Apxl 都定位到了 F2 - F3 带，这定义了人类和小鼠 X 染色体之间一种新的重排。