Rugarli E I, Adler D A, Borsani G, Tsuchiya K, Franco B, Hauge X, Disteche C, Chapman V, Ballabio A
Telethon Institute of Genetics and Medicine (TIGEM), San Raffaele Biomedical Science Park, Milano, Italy.
Nat Genet. 1995 Aug;10(4):466-71. doi: 10.1038/ng0895-466.
We report the unprecedented finding of a gene with a different map position in two mouse strains. The Clcn4 gene was found to map to the X chromosome in the wild Mediterrean mouse, Mus spretus but to chromosome 7 in the inbred strain of laboratory mouse C57BL/6J. These data indicate that a recent evolutionary rearrangement occurred on the mouse sex chromosomes, very close to the pseudoautosomal region. Our data provide molecular evidence for a major divergence near the pseudoautosomal region, consistent with the hypothesis that hybrid sterility in these species results from abnormal pairing of sex chromosomes during male meiosis.
一个基因在两种小鼠品系中的图谱位置不同。发现Clcn4基因在野生地中海小鼠（小家鼠）中定位于X染色体，但在实验室小鼠C57BL/6J的近交系中定位于7号染色体。这些数据表明，小鼠性染色体上最近发生了进化重排，且非常接近拟常染色体区域。我们的数据为拟常染色体区域附近的重大差异提供了分子证据，这与这些物种的杂种不育是由雄性减数分裂期间性染色体异常配对导致的这一假设相一致。
