Sandor V, Cuparencu B
Pharmacology. 1977;15(3):208-17. doi: 10.1159/000136691.
Apomorphine administered in reserpine-induced as well as in restraint ulcers in rats, failed to afford protection. Pimozide, moperone, trifluperidol and chlorpromazine fail to influence the development of the experimental ulcers. Pimozide and moperone although antagonizing the behavioral changes of amphetamine, maintained its antiulcer activity. Amitryptiline, cocaine and morphine had a protective activity. L-Dopa afforded a significant protection which was abolished if this compound was administered together with FLA-63, a specific dopamine-beta-hydroxilase inhibitor. These results were explained by admitting that not dopamine, but noradrenaline was responsible for the antiulcer activity. alpha-Methyl-dopa produced a significant protection in both experimental models.
阿扑吗啡对利血平诱导的以及束缚引起的大鼠溃疡均无保护作用。匹莫齐特、莫哌隆、三氟哌啶醇和氯丙嗪均不影响实验性溃疡的发展。匹莫齐特和莫哌隆虽然能拮抗苯丙胺的行为变化，但仍保持其抗溃疡活性。阿米替林、可卡因和吗啡具有保护活性。左旋多巴提供了显著的保护作用，但如果该化合物与特异性多巴胺-β-羟化酶抑制剂FLA-63一起给药，这种保护作用就会消失。这些结果可以解释为，不是多巴胺，而是去甲肾上腺素具有抗溃疡活性。α-甲基多巴在两种实验模型中均产生了显著的保护作用。
