7,12-二甲基苯并[a]蒽诱导金黄叙利亚仓鼠产生的“早期”鳞状细胞癌：一种动物模型的评估以及与上呼吸道消化道人类“早期”鳞状细胞癌形式的比较
7,12-dimethylbenz[a]anthracene-induced 'early' squamous cell carcinoma in the Golden Syrian hamster: evaluation of an animal model and comparison with 'early' forms of human squamous cell carcinoma in the upper aero-digestive tract.
作者信息
Andrejevic S, Savary J F, Fontolliet C, Monnier P, van Den Bergh H
机构信息
Department of Otolaryngology, Head and Neck Surgery--CHUV Hospital, Lausanne, Switzerland.
出版信息
Int J Exp Pathol. 1996 Feb;77(1):7-14. doi: 10.1046/j.1365-2613.1996.956095.x.
Abstract
To test and optimize photodynamic therapy of early cancers in the upper aero-digestive tract and oesophagus, we sought an appropriate animal model, which was found in the 7,12-dimethylbenz[a]anthracene-induced early squamous cell carcinoma in the Golden Syrian hamster. This chemically induced neoplasm is shown, by histology and immunohistochemistry, to pass through similar stages of early cancer development as its human counterpart. Its time sequence is highly reproducible, leading to a well differentiated carcinoma in situ and microinvasive carcinoma in the hamster cheek pouch over a period of 10 weeks.
摘要
为了测试和优化上呼吸道消化道及食管早期癌症的光动力疗法，我们寻找了一种合适的动物模型，在金黄叙利亚仓鼠经7,12 - 二甲基苯并[a]蒽诱导产生的早期鳞状细胞癌中找到了该模型。通过组织学和免疫组织化学研究表明，这种化学诱导的肿瘤在早期癌症发展过程中经历的阶段与其人类对应物相似。其时间顺序具有高度可重复性，在10周的时间内，可在仓鼠颊囊中导致高分化原位癌和微浸润癌。
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