Mahy I R, Lewis D M, Shore A C, Penney M D, Smith L D, Tooke J E
Department of Vascular Medicine, University of Exeter.
Heart. 1996 May;75(5):509-12. doi: 10.1136/hrt.75.5.509.
In vitro and in vivo evidence suggests that atrial natriuretic peptide can enhance fluid flux from intravascular to extravascular compartments. The relevance of this to human pathophysiology remains unclear.
To determine whether a central haemodynamic change associated with increased plasma concentrations of atrial natriuretic peptide produces detectable change in the capillary filtration coefficient in a peripheral microvascular bed.
12 patients with programmable dual chamber permanent pacemakers.
Calf capillary filtration coefficient (using a modified plethysmographic technique) and plasma atrial natriuretic peptide concentrations were measured during atrioventricular synchronous and ventricular pacing.
Atrioventricular asynchrony was associated with higher mean (SD) concentrations of atrial natriuretic peptide (231.9 (123.1) v 53.5 (38.8) pg/ml) and an increased mean (SD) calf capillary filtration coefficient (4.2 (1.1) v 3.6 (1.1) ml/min.mm Hg.100 ml x 10(-3)), but there was no correlation between the magnitude of the change in these variables in individual patients.
The peripheral capillary filtration coefficient may change in response to altered central haemodynamics. Atrial natriuretic peptide remains one potential candidate mechanism, but other factors are also likely to be involved.
体外和体内证据表明，心房利钠肽可增强液体从血管内到血管外间隙的通量。其与人类病理生理学的相关性仍不清楚。
确定与血浆心房利钠肽浓度升高相关的中心血流动力学变化是否会在外周微血管床的毛细血管滤过系数中产生可检测到的变化。
12例植入可编程双腔永久起搏器的患者。
在房室同步起搏和心室起搏期间测量小腿毛细血管滤过系数（采用改良体积描记技术）和血浆心房利钠肽浓度。
房室不同步与较高的平均（标准差）心房利钠肽浓度相关（231.9（123.1）对53.5（38.8）pg/ml）以及较高的平均（标准差）小腿毛细血管滤过系数（4.2（1.1）对3.6（1.1）ml/min·mmHg·100ml×10⁻³），但个体患者这些变量变化的幅度之间无相关性。
外周毛细血管滤过系数可能会因中心血流动力学改变而变化。心房利钠肽仍是一种潜在的候选机制，但其他因素可能也参与其中。
