Shanmugasundaram K R, Srinivas K, Sundaram P, Sathyaraj D, Muthu R, Padma P, Maheswari R U, Veeraraghavan V, Sharada V, Amudha B
Department of Biochemistry, University of Madras, Taramani, India.
J Cardiovasc Risk. 1995 Dec;2(6):551-61.
To establish the normal lipoprotein profile in the population and identify the early warning signs of coronary heart disease (CHD).
Random blood sampling of healthy adults and patients with symptomatic CHD including that complicated with acute myocardial infarction.
Plasma lipids, lipoproteins, lipid peroxidation, antioxidant enzymes and scavengers, red-cell membrane lipids and glycoproteins were assayed.
The normal levels of plasma lipids and lipoproteins were established. Levels of plasma free fatty acids, fibrinogen, white blood cell counts, echinocytes, red-cell membrane lipids and protein-bound carbohydrate components are significantly higher in healthy subjects with coronary risk index above 4.5 than they are in normal individuals. Antioxidant defences appear to be the distinguishing factor, remaining higher in normal individuals and thus keeping lipid peroxidation under control. In symptomatic CHD, antioxidant defences are significantly lowered.
建立人群正常脂蛋白谱并确定冠心病（CHD）的早期预警信号。
对健康成年人及有症状的冠心病患者（包括合并急性心肌梗死的患者）进行随机血液采样。
检测血浆脂质、脂蛋白、脂质过氧化、抗氧化酶和清除剂、红细胞膜脂质和糖蛋白。
确立了血浆脂质和脂蛋白的正常水平。冠心病风险指数高于4.5的健康受试者的血浆游离脂肪酸、纤维蛋白原、白细胞计数、棘红细胞、红细胞膜脂质和蛋白质结合碳水化合物成分水平显著高于正常个体。抗氧化防御似乎是区分因素，在正常个体中保持较高水平，从而控制脂质过氧化。在有症状的冠心病患者中，抗氧化防御显著降低。
