Matsumoto H, Yamane T, Inagake M, Nakatani H, Iwata Y, Takahashi T, Nishimura H, Nishino H, Nakagawa K, Miyazawa T
First Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
Cancer Lett. 1996 Jul 12;104(2):205-9. doi: 10.1016/0304-3835(96)04248-6.
Phosphatidylcholine hydroperoxide (PCOOH) measured using a chemiluminescence detector to examine colonic mucosal lipid hyperoxidation increased after injection of 1,2-dimethylhydrazine and green tea extract (GTE), which we previously showed inhibited carcinogenesis and oxidative DNA damage in the gastrointestinal tract. Therefore, the hyperoxidation of membrane phospholipids reflected well the degree of DNA damage and carcinogenic alteration, and may be a useful intermediate biomarker for initiation of carcinogenesis.
使用化学发光检测器测量的磷脂酰胆碱氢过氧化物（PCOOH）用于检测结肠黏膜脂质过氧化，在注射1,2 - 二甲基肼和绿茶提取物（GTE）后增加，我们之前的研究表明绿茶提取物可抑制胃肠道的致癌作用和氧化性DNA损伤。因此，膜磷脂的过氧化很好地反映了DNA损伤和致癌改变的程度，并且可能是癌症发生起始阶段一个有用的中间生物标志物。
