绿茶提取物对大鼠1,2 - 二甲基肼诱导的氧化性DNA损伤的抑制作用
Inhibition of 1,2-dimethylhydrazine-induced oxidative DNA damage by green tea extract in rat.
作者信息
Inagake M, Yamane T, Kitao Y, Oya K, Matsumoto H, Kikuoka N, Nakatani H, Takahashi T, Nishimura H, Iwashima A
机构信息
First Department of Surgery, Kyoto Prefectural University of Medicine.
出版信息
Jpn J Cancer Res. 1995 Nov;86(11):1106-11. doi: 10.1111/j.1349-7006.1995.tb03027.x.
Abstract
Following subcutaneous injection of 1,2-dimethylhydrazine (DMH), which is carcinogenic to rat colon and liver, to Sprague-Dawley rats, a significant increase of 8-hydroxydeoxyguanosine (8-OHdG) was observed in the DNA of colonic mucosa and liver. The 8-OHdG formation reached the maximal level at about 24 h after the DMII injection. On the other hand, no increase of 8-OHdG was observed in the DNA of the kidney. Drinking green tea extract (GTE) for ten days prior to the DMH injection significantly inhibited the formation of 8-OHdG in the colon. These findings demonstrate that DMH causes oxidative damage to the DNA of its target organ, and that GTE protects colonic mucosa from this oxidative damage.
摘要
给斯普拉格-道利大鼠皮下注射对大鼠结肠和肝脏具有致癌性的1,2-二甲基肼（DMH）后，在结肠黏膜和肝脏的DNA中观察到8-羟基脱氧鸟苷（8-OHdG）显著增加。8-OHdG的形成在DMH注射后约24小时达到最高水平。另一方面，在肾脏的DNA中未观察到8-OHdG增加。在注射DMH前饮用绿茶提取物（GTE）十天可显著抑制结肠中8-OHdG的形成。这些发现表明，DMH对其靶器官的DNA造成氧化损伤，而GTE可保护结肠黏膜免受这种氧化损伤。
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