Stanley M, Traskman-Bendz L, Dorovini-Zis K
Life Sci. 1985 Oct 7;37(14):1279-86. doi: 10.1016/0024-3205(85)90242-5.
Brain and cerebrospinal fluid (CSF) levels of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) were simultaneously measured in 48 individuals at autopsy. Concentrations of 5-HIAA and HVA in the cerebral cortex were positively correlated with their levels in the CSF for the same individual. Additionally a positive correlation was observed between postmortem CSF levels of 5-HIAA and HVA and a significant concentration gradient for both metabolites was observed in serial fractions of CSF. These findings suggest that determinations of 5-HIAA and HVA in CSF from living individuals may reflect brain metabolite levels as well as the functional activity of these specific neuronal systems.
在48例尸检个体中同时测量了大脑和脑脊液（CSF）中高香草酸（HVA）和5-羟吲哚乙酸（5-HIAA）的水平。同一受试者大脑皮质中5-HIAA和HVA的浓度与脑脊液中的水平呈正相关。此外，还观察到死后脑脊液中5-HIAA和HVA水平呈正相关，并且在脑脊液的连续组分中观察到这两种代谢物都有显著的浓度梯度。这些发现表明，测定活体脑脊液中的5-HIAA和HVA可能反映脑代谢物水平以及这些特定神经元系统的功能活性。
