Javadpour N, Hyatt C L, Soares T
J Surg Oncol. 1979;11(2):153-9. doi: 10.1002/jso.2930110209.
Certain in vivo and in vitro immunologic features of carcinogen-induced murine bladder cancer have been studied. The consistency of tumor induction, its natural history, and immunogenicity both in vivo and in vitro render this syngeneic murine bladder tumor a suitable model for immunologic studies. Pre-immunization of strain C3H/Hen mice with mid-gestational fetal cells did not protect the animals from tumor challenge. Sera of mice immunized with mid-gestational fetal cells were not cytotoxic to cultured tumor cells in a microcytotoxicity assay indicative of dissimilarity between the tumor associated antigen and the syngeneic mid-gestational fetal antigen.
人们已经对致癌物诱导的小鼠膀胱癌的某些体内和体外免疫学特征进行了研究。肿瘤诱导的一致性、其自然病史以及体内和体外的免疫原性，使得这种同基因小鼠膀胱肿瘤成为免疫学研究的合适模型。用妊娠中期胎儿细胞对C3H/Hen品系小鼠进行预免疫，并不能保护动物免受肿瘤攻击。在用妊娠中期胎儿细胞免疫的小鼠血清在微细胞毒性试验中对培养的肿瘤细胞没有细胞毒性，这表明肿瘤相关抗原与同基因妊娠中期胎儿抗原不同。
