B细胞敲除小鼠中CD4 + T细胞的激活与耐受性诱导
CD4+ T cell activation and tolerance induction in B cell knockout mice.
作者信息
Phillips J A, Romball C G, Hobbs M V, Ernst D N, Shultz L, Weigle W O
机构信息
Department of Immunology, Scripps Research Institute, La Jolla, California 92037, USA.
出版信息
J Exp Med. 1996 Apr 1;183(4):1339-44. doi: 10.1084/jem.183.4.1339.
Abstract
B cell knockout mice microMT/microMT were used to examine the requirement for B cell antigen (Ag) presentation in the establishment of CD4+ T cell tolerance. CD4+T cells from microMT mice injected with exogenous protein Ag in adjuvant responded to in vitro challenge by transcription of cytokine mRNA, cytokine secretion, and proliferation. Peripheral tolerance could be established in microMT mice with a single dose of deaggragated protein. This tolerance was manifested by a loss of T cell proliferation and cytokine production (including both T helper cell type 1 [Th1]- and Th2-related cytokines), indicating that B cells are not required for the induction of peripheral T cell tolerance and suggesting that the dual zone tolerance theory is not applicable to all protein Ags and is not mediated through Ag presentation by B cells.
摘要
利用B细胞敲除小鼠（microMT/microMT）来检测在建立CD4+ T细胞耐受性过程中对B细胞抗原（Ag）呈递的需求。给microMT小鼠注射佐剂中的外源性蛋白质抗原后，其CD4+ T细胞通过细胞因子mRNA转录、细胞因子分泌和增殖对体外刺激产生反应。用单剂量的解聚蛋白可在microMT小鼠中建立外周耐受性。这种耐受性表现为T细胞增殖和细胞因子产生（包括1型辅助性T细胞[Th1]和Th2相关细胞因子）的丧失，表明诱导外周T细胞耐受性不需要B细胞，并提示双区耐受性理论不适用于所有蛋白质抗原，且不是通过B细胞呈递抗原介导的。
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