B 细胞在移植中的新功能。
Novel functions of B cells in transplantation.
机构信息
Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA.
出版信息
Curr Opin Organ Transplant. 2011 Feb;16(1):61-8. doi: 10.1097/MOT.0b013e328342551c.
PURPOSE OF REVIEW
This manuscript reviews current knowledge and recent findings regarding antibody-independent functions of B cells in transplantation.
RECENT FINDINGS
Until recently the functions of B cells in transplantation have been attributed almost entirely to the antibodies they produce. However, the results of recent trials of B-cell-depleting agents for treatment of antibody-mediated rejection as well as auto-immune disease raised awareness that B cells mediate functions independent of antibody synthesis.
SUMMARY
These 'nonclassical' functions place B cells at the center of immune regulation with the power to enhance or inhibit immunity.
目的综述
本文综述了当前关于 B 细胞在移植中的抗体非依赖性功能的知识和最新发现。
最近的发现
直到最近，B 细胞在移植中的功能几乎完全归因于它们产生的抗体。然而，最近用 B 细胞耗竭剂治疗抗体介导的排斥反应和自身免疫性疾病的试验结果引起了人们的注意，即 B 细胞介导的功能不依赖于抗体合成。
总结
这些“非经典”功能使 B 细胞成为免疫调节的中心，具有增强或抑制免疫的能力。
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