在缺乏RAG-2表达的情况下，前体B细胞中RAG-1蛋白的半衰期会延长。
The half-life of RAG-1 protein in precursor B cells is increased in the absence of RAG-2 expression.
作者信息
Grawunder U, Schatz D G, Leu T M, Rolink A, Melchers F
机构信息
Basel Institute for Immunology, Switzerland.
出版信息
J Exp Med. 1996 Apr 1;183(4):1731-7. doi: 10.1084/jem.183.4.1731.
Abstract
Site-specific recombination of immunoglobulin and T cell receptor gene segments in B and T lymphocytes is dependent on the expression of two recombinant activation genes, Rag-1 and Rag-2. Here, we show that RAG-1 protein turnover in pre-B cells depends on the expression of RAG-2. The apparent half-life of RAG-1 protein is increased when RAG-2 is not expressed in differentiating pre-B cells.
摘要
B淋巴细胞和T淋巴细胞中免疫球蛋白和T细胞受体基因片段的位点特异性重组依赖于两个重组激活基因Rag-1和Rag-2的表达。在此，我们表明前B细胞中RAG-1蛋白的周转依赖于RAG-2的表达。当RAG-2在分化的前B细胞中不表达时，RAG-1蛋白的表观半衰期会延长。
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