豚鼠肺在过敏反应期间释放的类前列腺素物质的药理学。

The pharmacology of prostaglandin-like substances released from guinea-pig lungs during anaphylaxis.

作者信息

Boot J R, Dawson W, Cockerill A F, Mallen D N, Osborne D J

出版信息

Prostaglandins. 1977 May;13(5):927-32. doi: 10.1016/0090-6980(77)90222-2.

Abstract

The pharmacology of the prostaglandins (PGs) and thromboxanes (Txs) released from immunologically challenged guinea-pig lungs is related to their roles in the anaphylactic response. 6-oxo-PGF1alpha probably contibutes substantially to bronchoconstriction during anaphylaxis. TxB2 may contribute to the anaphylactic response by increasing SRA-A release and by stimulating leucotaxis. The 15-oxo metabolites of PGE2 and PGF2alpha are rather weak spasmogens, but might modify respiratory muscle contractions and pulmonary vascular resistance. The 15-oxo 13,14 dihydro metabolites of PGE2 PGF2alpha and TxB2 were inactive in the systems studied, suggesting an important inactivating role for the 13:14 reductase enzyme.

摘要

免疫攻击的豚鼠肺释放的前列腺素（PGs）和血栓素（Txs）的药理学与其在过敏反应中的作用相关。6-氧代-PGF1α可能在过敏反应期间对支气管收缩起主要作用。血栓素B2（TxB2）可能通过增加慢反应物质-A（SRA-A）释放和刺激白细胞趋化作用而导致过敏反应。前列腺素E2（PGE2）和前列腺素F2α（PGF2α）的15-氧代代谢产物是相当弱的致痉剂，但可能会改变呼吸肌收缩和肺血管阻力。PGE2、PGF2α和TxB2的15-氧代-13,14-二氢代谢产物在所研究的系统中无活性，提示13:14还原酶具有重要的失活作用。