Hernández A M, Arias A, Felipe A, Alvarez R, Sierra A
Preventive Medicine and Public Health, University of La Laguna, Santa Cruz de Tenerife, Spain.
J Chemother. 1995 Dec;7(6):503-8. doi: 10.1179/joc.1995.7.6.503.
The authors investigated the in vitro susceptibility to antimicrobial agents of 220 Mycobacterium fortuitum isolates originating from clinical samples (14) of patients attending the Hospital Universitario de Canarias and Hospital del Tórax, and from environmental sources (206): 3 from sea water, 10 from the water supply and 193 from sewage. The Minimum Inhibitory Concentration (MIC) was calculated using the broth microdilution method with Mueller-Hinton Broth without supplement. Amikacin was the most efficacious antimicrobial agent against all the isolates of M. fortuitum with an MIC which was considerably lower than its critical concentration. The good results achieved with amikacin in vitro are confirmed by those obtained in vivo, with patients infected with M. fortuitum. No significant difference was found in the efficacy of amikacin and ofloxacin against all the isolates assayed.
作者调查了220株偶然分枝杆菌分离株对抗菌药物的体外敏感性，这些分离株来自加那利大学医院和托拉克斯医院患者的临床样本（14株）以及环境来源（206株）：3株来自海水，10株来自供水系统，193株来自污水。采用无补充剂的 Mueller-Hinton 肉汤通过肉汤微量稀释法计算最低抑菌浓度（MIC）。阿米卡星是对所有偶然分枝杆菌分离株最有效的抗菌药物，其MIC远低于其临界浓度。在感染偶然分枝杆菌的患者体内所获得的结果证实了阿米卡星在体外取得的良好效果。在对所有检测的分离株的作用效果上，未发现阿米卡星和氧氟沙星之间存在显著差异。
