霍乱弧菌非O1群环境分离株产生新型霍乱毒素。
Production of the new cholera toxin by environmental isolates of Vibrio cholerae non-O1.
作者信息
Singh D V, Tikoo A, Sanyal S C
机构信息
Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
出版信息
J Med Microbiol. 1996 Jul;45(1):31-4. doi: 10.1099/00222615-45-1-31.
One of five strains of Vibrio cholerae non-O1 isolated from environmental sources caused fluid accumulation in an initial rabbit ileal loop (RIL) test. The four strains that caused little or no accumulation of fluid gave a positive response after one-to-three consecutive passages through RILs. The amount of fluid produced increased after each passage. Filtrates of cultures of all five environmental isolates caused fluid accumulation similar to that produced by live cells. The enterotoxin showed a precipitin band with new cholera antitoxin and was neutralised completely by new cholera antitoxin diluted 1 in 32, indicating its close immunobiological relationship to the new cholera toxin. The present study indicates that V. cholerae non-O1 strains produce an enterotoxin that is similar to the new cholera toxin.
从环境源分离出的五株霍乱弧菌非O1菌株中的一株，在初始兔回肠袢（RIL）试验中导致液体蓄积。另外四株导致很少或没有液体蓄积的菌株，在连续通过RIL一至三次后呈阳性反应。每次传代后产生的液体量增加。所有五株环境分离株的培养滤液均导致与活细胞产生的液体蓄积相似的情况。该肠毒素与新的霍乱抗毒素显示出一条沉淀带，并被稀释为1/32的新霍乱抗毒素完全中和，表明其与新霍乱毒素有密切的免疫生物学关系。本研究表明，霍乱弧菌非O1菌株产生一种与新霍乱毒素相似的肠毒素。
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