Tang Wei, Inagaki Yoshinori, Kokudo Norihiko, Guo Qian, Seyama Yasuji, Nakata Munehiro, Imamura Hiroshi, Sano Keiji, Sugawara Yasuhiko, Makuuchi Masatoshi
Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo, Tokyo 113-8655, Japan.
World J Gastroenterol. 2005 Sep 21;11(35):5450-4. doi: 10.3748/wjg.v11.i35.5450.
To assess histochemical expression of KL-6 and its clinicopathological significance in carcinoma of the ampulla of Vater.
Ampullary carcinoma tissues were collected from 38 patients who underwent pancreatoduodenectomy or local resection. Tissues were subjected to immunohistochemical analysis using KL-6 antibody.
Positive staining of ampullary carcinoma cells was observed in 26 (68.4%) cases. Staining was not found in the surrounding non-cancer regions of the ampullary tissues. Remarkable KL-6 expression was observed in invasive carcinoma cells in pancreatic and duodenal tissues and in metastatic carcinoma cells in lymph nodes. Positive KL-6 expression was related to lymph node metastasis (P = 0.020), pancreatic invasion (P = 0.016), duodenal invasion (P = 0.034), and advanced stage of TNM clinical classification (P = 0.010). Survival analysis showed that positive expression of KL-6 was related to a poorer prognosis (P = 0.029).
The aberrant expression of KL-6 mucin is significantly related to unfavorable behaviors of carcinoma of the ampulla of Vater.
评估KL-6在壶腹癌中的组织化学表达及其临床病理意义。
收集38例行胰十二指肠切除术或局部切除术患者的壶腹癌组织。采用KL-6抗体对组织进行免疫组化分析。
26例（68.4%）壶腹癌细胞呈阳性染色。在壶腹组织周围的非癌区域未发现染色。在胰腺和十二指肠组织的浸润癌细胞以及淋巴结转移癌细胞中观察到显著的KL-6表达。KL-6阳性表达与淋巴结转移（P = 0.020）、胰腺浸润（P = 0.016）、十二指肠浸润（P = 0.034）及TNM临床分期晚期（P = 0.010）相关。生存分析表明，KL-6阳性表达与预后较差相关（P = 0.029）。
KL-6黏蛋白的异常表达与壶腹癌的不良行为显著相关。
