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TFG/TAF30/ANC1，酵母SWI/SNF复合物的一个组分，与白血病致病蛋白ENL和AF-9相似。

TFG/TAF30/ANC1, a component of the yeast SWI/SNF complex that is similar to the leukemogenic proteins ENL and AF-9.

作者信息

Cairns B R, Henry N L, Kornberg R D

机构信息

Department of Structural Biology, Stanford University School of Medicine, California 94305, USA.

出版信息

Mol Cell Biol. 1996 Jul;16(7):3308-16. doi: 10.1128/MCB.16.7.3308.

DOI:10.1128/MCB.16.7.3308
PMID:8668146
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC231325/
Abstract

The SWI1/ADR6, SWI2/SNF2, SWI3, SNF5, and SNF6 gene products are all required for proper transcriptional control of many genes in the yeast Saccharomyces cerevisiae. Genetic studies indicated that these gene products might form a multiprotein SWI/SNF complex important for chromatin transitions preceding transcription from RNA polymerase II promoters. Biochemical studies identified a SWI/SNF complex containing these and at least six additional polypeptides. Here we show that the 29-kDa component of the SWI/SNF complex is identical to TFG3/TAF30/ANC1. Thus, a component of the SWI/SNF complex is also a member of the TFIIF and TFIID transcription complexes. TFG3 interacted with the SNF5 component of the SWI/SNF complex in protein interaction blots. TFG3 is significantly similar to ENL and AF-9, two proteins implicated in human acute leukemia. These results suggest that ENL and AF-9 proteins interact with the SNF5 component of the human SWI/SNF complex and raise the possibility that the SWI/SNF complex is involved in acute leukemia.

摘要

SWI1/ADR6、SWI2/SNF2、SWI3、SNF5和SNF6基因产物对于酿酒酵母中许多基因的正确转录调控都是必需的。遗传学研究表明，这些基因产物可能形成一种多蛋白SWI/SNF复合物，对RNA聚合酶II启动子转录之前的染色质转变很重要。生化研究鉴定出一种包含这些以及至少六种其他多肽的SWI/SNF复合物。我们在此表明，SWI/SNF复合物的29 kDa组分与TFG3/TAF30/ANC1相同。因此，SWI/SNF复合物的一个组分也是TFIIF和TFIID转录复合物的成员。在蛋白质相互作用印迹中，TFG3与SWI/SNF复合物的SNF5组分相互作用。TFG3与ENL和AF-9显著相似，这两种蛋白质与人类急性白血病有关。这些结果表明，ENL和AF-9蛋白与人类SWI/SNF复合物的SNF5组分相互作用，并增加了SWI/SNF复合物参与急性白血病的可能性。

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本文引用的文献

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