Kupietzky A, Holan G, Shapira J
Hebrew University--Hadassah School of Dental Medicine, Department of Pediatric Dentistry, Jerusalem, Israel.
Pediatr Dent. 1996 Jan-Feb;18(1):32-4.
Providing amnesia about a surgery is a desired side effect of a medication. This study compares anterograde amnesic effects of midazolam with hydroxyzine in children undergoing dental treatment with those drugs plus nitrous oxide, using a recall test. Thirty ASAI children 24-28 months, were shown a Standard-Binet intelligence scale-memory for objects subtest before entering treatment room. Twenty-lone randomly determined children received 3.7 mg/kg hydroxyzine 45 min before treatment or 0.2 mg/kg intranasal midazolam in two succeeding appointments, alternatively. Recall in the 30-subject treatment group was 90%. Recall in the 21-subject treatment group was 71% for hydroxyzine and 29% for midazolam. Midazolam was more effective in creating amnesia than hydroxyzine in this study.
产生手术失忆是一种药物期望的副作用。本研究采用回忆测试，比较了咪达唑仑与羟嗪在接受牙科治疗的儿童中与一氧化二氮联合使用时的顺行性遗忘效果。30名24至28个月大的ASA I级儿童在进入治疗室前接受了标准比内智力量表物体记忆子测试。21名随机确定的儿童在治疗前45分钟接受3.7毫克/千克羟嗪，或在两次连续预约中交替接受0.2毫克/千克鼻内咪达唑仑。30名受试者治疗组的回忆率为90%。21名受试者治疗组中，羟嗪的回忆率为71%，咪达唑仑的回忆率为29%。在本研究中，咪达唑仑在产生失忆方面比羟嗪更有效。
