Shapira J, Holan G, Botzer E, Kupietzky A, Tal E, Fuks A B
Department of Pediatric Dentistry, Hebrew University, Hadassah Faculty of Dental Medicine, Jerusalem, Israel.
ASDC J Dent Child. 1996 Nov-Dec;63(6):421-5.
The purpose of the study was to compare hydroxyzine (HYD) and 0.2mg/Kg midazolam (MDZ) as sedative agents for young pediatric dental patients. Twenty-nine healthy two-to-four-year-old children participated in the study. Hydroxyzine was dripped nasally 10 minutes before treatment. The patient's crying, alertness, movement and general behavior were blindly assessed and statistically analyzed. No differences were found between the mean general behavior scores nor between the first and second visits in both groups. A significant difference (p < 0.02) was found in the acceptance of the face and nasal masks by children of the midazolam group between the first and second appointments. None of the children of this group cried nor moved at the first visit. The results of the study indicate that midazolam is somewhat more effective than hydroxyzine as a sedative agent for short procedures in young pediatric dental patients.
本研究的目的是比较羟嗪（HYD）和0.2mg/Kg咪达唑仑（MDZ）作为幼儿牙科患者镇静剂的效果。29名健康的2至4岁儿童参与了该研究。在治疗前10分钟经鼻滴入羟嗪。对患者的哭闹、警觉性、活动和一般行为进行盲法评估并进行统计学分析。两组的平均一般行为评分之间以及首次和第二次就诊之间均未发现差异。咪达唑仑组儿童在首次和第二次预约时对面罩和鼻罩的接受度存在显著差异（p < 0.02）。该组儿童在首次就诊时均未哭闹或活动。研究结果表明，在幼儿牙科患者的短时间手术中，咪达唑仑作为镇静剂比羟嗪更有效。
