Braunsberg H
Ric Clin Lab. 1977 Jan-Mar;7(1):47-74. doi: 10.1007/BF02886602.
Work leading to the concept of hormone responsiveness of human breast cancer and current views of the mode of action of oestrogens in target tissues are reviewed. Results of oestrogen receptor assays are considered in relation to clinical response to tumours to endocrine therapy and difficulties encountered in the interpretation of receptor determinations are discussed. Recent work on the distribution of different forms of the oestrogen receptors in human tumours and their relation to clinical response may lead to better selection of patients for endocrine therapy. Results of receptor assays in male patients with breast cancer, in benign breast tumours and in malignant tumours at sites other than breast are reviewed, and work on receptors for hormones other than oestrogens is discussed briefly. Further work is needed on the integrity of the receptor mechanism in tumour cells and on the effects of hormone treatment. Methods for the separation and estimation of oestrogen receptors in human tumour tissue are reviewed and discussed. Errors arising during collection, storage and analysis are considered. Different ways of calculating and expressing results of these assays are mentioned. It is suggested that more accurate determinations of oestrogen receptors may lead to better discrimination between hormone responsive and unresponsive human breast tumours.
本文回顾了有关人类乳腺癌激素反应性概念的相关研究工作以及目前对雌激素在靶组织中作用方式的观点。结合肿瘤对内分泌治疗的临床反应，对雌激素受体检测结果进行了考量，并讨论了受体测定结果解读中遇到的困难。近期关于人类肿瘤中不同形式雌激素受体分布及其与临床反应关系的研究，可能有助于更好地筛选适合内分泌治疗的患者。本文还回顾了男性乳腺癌患者、良性乳腺肿瘤以及乳腺以外部位恶性肿瘤的受体检测结果，并简要讨论了非雌激素类激素受体的研究工作。肿瘤细胞中受体机制的完整性以及激素治疗的效果仍需进一步研究。本文对人类肿瘤组织中雌激素受体的分离和测定方法进行了回顾与讨论。考虑了样本采集、储存和分析过程中产生的误差。提及了这些检测结果的不同计算和表达方法。研究表明，更准确地测定雌激素受体可能有助于更好地区分激素反应性和非反应性人类乳腺肿瘤。
