Koizumi J H
Department of Pathology, New York Hospital-Cornell University Medical College, New York 10021, USA.
Acta Cytol. 1996 May-Jun;40(3):519-28. doi: 10.1159/000333909.
To explore the possibility that artifact, such as externally applied mechanical stress, may contribute to the formation of nipplelike nuclear protrusions in certain predisposed cells.
The following specimens were examined for the presence and morphology of nipplelike protrusions: 100 endocervical smears, 40 bronchial specimens (brushings, washings and bronchoalveolar lavage) and fine needle aspirates of seven lactating adenomas and 10 fibroadenomas of the breast.
Nipplelike nuclear protrusions in endocervical cells were present in the majority of gynecologic endocervical smears showing abundant endocervical cells virtually regardless of menstrual status. They were observed frequently in bronchial specimens and fine needle aspirates of lactating adenoma of the breast.
It appears that nippling in cytologic preparations is a common phenomenon, particularly in benign endocervical and bronchial columnar cells, and may be found in other tissues and some neoplasms as well. The apparent nonspecificity of nippling, together with the association with other phenomena, such as nuclear "holes", stripped nuclei, nuclear distortion and cellular degeneration, strongly suggests that nippling may be largely the result of mechanical stress during smearing, brushing or other phases of specimen procurement or preparation. Nucleoli may serve as a nidus for nipple formation. Other qualities of a cell, including fragility and cytoplasmic features, may predispose it to the formation of nippling.
探讨诸如外部施加的机械应力等假象是否可能在某些易感细胞中导致乳头状核突出物的形成。
检查了以下标本中乳头状突出物的存在情况和形态：100份宫颈涂片、40份支气管标本（刷片、冲洗液和支气管肺泡灌洗液）以及7例乳腺泌乳性腺瘤和10例纤维腺瘤的细针穿刺抽吸物。
在大多数宫颈细胞涂片的宫颈细胞中均存在乳头状核突出物，无论月经状态如何，这些涂片显示宫颈细胞丰富。在支气管标本和乳腺泌乳性腺瘤的细针穿刺抽吸物中也经常观察到。
细胞学标本中的乳头样现象似乎是一种常见现象，尤其是在良性宫颈和支气管柱状细胞中，在其他组织和一些肿瘤中也可能出现。乳头样现象明显的非特异性，以及与其他现象如核“空洞”、裸核、核变形和细胞变性的关联，强烈提示乳头样现象可能主要是涂片、刷片或标本采集或制备的其他阶段中机械应力的结果。核仁可能是乳头形成的起始部位。细胞的其他特性，包括脆性和细胞质特征，可能使其易于形成乳头样现象。
