Cytologic appearance of sinus histiocytosis with massive lymphadenopathy: a case report.

BACKGROUND

Sinus histiocytosis with massive lymphadenopathy is a benign, massive lymphadenopathy, usually cervical, of unknown etiology.

CASE

Cytologic smears revealed a polymorphic population of cells consisting of mature lymphocytes, plasma cells, occasional neutrophils and many histiocytes, characteristically showing emperipolesis. A reactive lymphadenopathy was diagnosed. The histopathologic diagnosis on open biopsy specimen was sinus histiocytosis with massive lymphadenopathy.

CONCLUSION

Cytologic diagnosis of sinus histiocytosis with massive lymphadenopathy is possible with high accuracy provided that the cytologic findings are interpreted in the appropriate clinical context. The cytologic examination also can help with follow-up.