Shi Yuquan, Griffin Adrienne Carruth, Zhang Paul Jl, Palmer James N, Gupta Prabodh
Department of Pathology and Laboratory Medicine, Pennsylvania Hospital, Philadelphia, PA, USA.
Cytojournal. 2011 Feb 12;8:3. doi: 10.4103/1742-6413.76731.
Rosai-Dorfman disease (RDD), a rare, benign, self-limiting histiocytic proliferative disorder, can be encountered in both nodal and extranodal locations, and fine needle aspiration (FNA), a simple, accurate and economic tool, has been widely used for the diagnosis of superficial and deep-seated lesions. Familiarity with the cytomorphologic features of RDD is important as prognosis and treatment are quite different from other benign or malignant diseases for which it may clinically masquerade. Although large numbers of RDD cases have been reported, review of the literature has revealed 49 reported cases of RDD diagnosed by FNA. Here, we report a case of RDD with nasal and sinus involvement. The patient was seen at our institution, carrying a diagnosis of inflammatory pseudotumor rendered by an outside institution, based on material obtained by nasal and sinus surgical biopsies. Cervical lymph node FNA performed at our institution revealed typical features of RDD. The case, as well as a brief review of the literature and 49 RDD cases with FNA cytology, will be discussed.
罗萨伊-多夫曼病（RDD）是一种罕见的、良性的、自限性组织细胞增生性疾病，可发生于淋巴结和结外部位。细针穿刺抽吸活检（FNA）作为一种简单、准确且经济的手段，已被广泛用于浅表和深部病变的诊断。熟悉RDD的细胞形态学特征很重要，因为其预后和治疗与临床上可能与之混淆的其他良性或恶性疾病有很大不同。尽管已经报道了大量RDD病例，但文献回顾显示仅有49例通过FNA诊断的RDD病例。在此，我们报告1例累及鼻腔和鼻窦的RDD病例。该患者在我院就诊，外院基于鼻腔和鼻窦手术活检材料诊断为炎性假瘤。我院进行的颈部淋巴结FNA显示出RDD的典型特征。本文将讨论该病例以及对文献的简要回顾和49例有FNA细胞学结果的RDD病例。
