Hogan D B, Ebly E M
Department of Medicine, University of Calgary, Alberta, Canada.
Age Ageing. 1995 Sep;24(5):375-81. doi: 10.1093/ageing/24.5.375.
We report on the prevalence of primitive reflexes (PR) and their association with cognitive, behavioural, functional and clinical characteristics in 2914 Canadians 65 years and older. Data were collected as part of the Canadian Study of Health and Aging (1990-92) and included individuals living in the community and in institutions. PR were more commonly found in demented subjects. Demented subjects with prehensile PR (i.e. grasp, traction, suck) had significantly more functional and behavioural problems and were more severely demented. The presence of any PR increased the likelihood of other neurological findings (e.g. bradykinesia). Vascular dementia (VD) cases were more likely to have unilateral primitive PR than probable Alzheimer's disease (Pro AD) and Parkinson's dementia (PD) cases. PD cases were more likely to have glabellar and traction responses. While more common among the demented, PR lacked sufficient sensitivity to be an early diagnostic tool for dementia. Prehensile PR may help to define particular types or severity of dementia.
我们报告了2914名65岁及以上加拿大人的原始反射（PR）患病率及其与认知、行为、功能和临床特征的关联。数据作为加拿大健康与老龄化研究（1990 - 1992年）的一部分收集，包括居住在社区和机构中的个体。PR在痴呆患者中更常见。有抓握性PR（即抓握、牵引、吸吮）的痴呆患者有更多的功能和行为问题，且痴呆程度更严重。任何PR的存在都会增加出现其他神经学表现（如运动迟缓）的可能性。血管性痴呆（VD）病例比可能的阿尔茨海默病（Pro AD）和帕金森病痴呆（PD）病例更有可能出现单侧原始反射。PD病例更有可能出现眉间反射和牵引反应。虽然PR在痴呆患者中更常见，但缺乏足够的敏感性作为痴呆的早期诊断工具。抓握性PR可能有助于定义特定类型或严重程度的痴呆。
