Amar K, Lewis T, Wilcock G, Scott M, Bucks R
Frenchay Hospital, University of Bristol.
Age Ageing. 1995 Sep;24(5):411-5. doi: 10.1093/ageing/24.5.411.
In order to discover the prevalence of white matter low attenuation (WMLA) in the brain and its relationship to vascular risk factors in our Memory Disorders Clinic patients we assessed brain CT scans of 202 patients referred to our clinic between January 1991 and December 1992. One hundred patients (49.5%) had WMLA, and the prevalence increased with increasing severity of cognitive impairment. It was 12% in patients with no evidence of dementia, 32% in those with isolated memory loss, and 59%) in patients with possible or probable dementia. There was a correlation between WMLA and systolic blood pressure, heart disease, peripheral vascular disease, focal neurological signs on examination and central atrophy on CT. No correlation was found between WMLA and low blood pressure, blood glucose or cholesterol level. Our findings indicate that WMLA probably plays an important role in cognitive impairment, and that thromboembolic rather than haemodynamic factors are probably more important in its pathogenesis.
为了发现我们记忆障碍门诊患者脑白质低衰减（WMLA）的患病率及其与血管危险因素的关系，我们评估了1991年1月至1992年12月间转诊至我们门诊的202例患者的脑部CT扫描结果。100例患者（49.5%）存在WMLA，且患病率随认知障碍严重程度的增加而升高。在无痴呆证据的患者中为12%，在仅有记忆力丧失的患者中为32%，在可能或很可能患有痴呆的患者中为59%。WMLA与收缩压、心脏病、外周血管疾病、检查时的局灶性神经体征以及CT上的脑萎缩之间存在相关性。未发现WMLA与低血压、血糖或胆固醇水平之间存在相关性。我们的研究结果表明，WMLA可能在认知障碍中起重要作用，并且在其发病机制中血栓栓塞因素而非血流动力学因素可能更为重要。
