Watt S J, Cook L B, Ohri S, Lockwood G G
Department of Anaesthetics, Hemel Hempstead General Hospital, Herts.
Anaesthesia. 1996 Jan;51(1):24-8. doi: 10.1111/j.1365-2044.1996.tb07648.x.
The hypothesis that anaesthetic uptake during maintenance of anaesthesia is related to cardiac output was tested on 21 patients undergoing cardiac surgery. Using a computer-controlled closed breathing system, enflurane was administered to maintain an end-expired concentration of 1%. Cardiac output was measured by thermodilution using a pulmonary artery catheter. A clear qualitative but not quantitative relationship was demonstrated. Changes in anaesthetic requirements at a constant end-expired concentration are a better guide to changes in cardiac output than changes in end-expired carbon dioxide with constant ventilation in patients undergoing cardiac surgery.
在21例接受心脏手术的患者身上测试了麻醉维持期间麻醉药摄取与心输出量相关的假设。使用计算机控制的闭合呼吸回路，给予安氟醚以维持呼出末浓度为1%。采用肺动脉导管通过热稀释法测量心输出量。结果显示出一种明确的定性关系，但非定量关系。在接受心脏手术的患者中，在呼出末浓度恒定的情况下麻醉需求的变化比在通气恒定的情况下呼出末二氧化碳的变化更能指导心输出量的变化。
