Shintani S, Funayama T, Yoshihama Y, Alcalde R E, Ootsuki K, Terakado N, Matsumura T
Department of Oral and Maxillofacial Surgery II, Okayama University Dental School, Japan.
Anticancer Res. 1995 Nov-Dec;15(6B):2623-6.
The tyrosine kinase receptor family, including the epidermal growth factor receptor (EGF-R), c-erbB2 and, more recently, the c-erbB3, has been recognized as being of particular importance in many human malignancies. This study was undertaken to define the role of c-erb B2 and c-erbB3 in adenoid cystic carcinomas (A.C.C.) of the salivary glands. Sixteen cases of A.C.C. were studied immunohistochemically, using antibodies against each erbB gene family product. EGF-R was not detected in any of these samples but c-erbB2 and c-erbB3 gene products (ERBB2and ERBB3) were demonstrated in all A.C.C. sections with some degree of straining. Tubular and cribriform patterns overexpressed particularly large amounts of ERBB2 and ERBB3. Strong staining was mainly demonstrated in tumor cells of the invasive area. These results suggested that overexpression of ERBB2 and ERBB3 is related to tumor differentiation and invasion in adenoid cystic carcinomas.
酪氨酸激酶受体家族，包括表皮生长因子受体（EGF-R）、c-erbB2以及最近发现的c-erbB3，已被认为在许多人类恶性肿瘤中具有特别重要的意义。本研究旨在确定c-erb B2和c-erbB3在涎腺腺样囊性癌（A.C.C.）中的作用。使用针对每个erbB基因家族产物的抗体，对16例A.C.C.进行了免疫组织化学研究。在这些样本中均未检测到EGF-R，但在所有A.C.C.切片中均显示出c-erbB2和c-erbB3基因产物（ERBB2和ERBB3），且有一定程度的染色。管状和筛状结构中ERBB2和ERBB3的表达量特别高。强染色主要出现在浸润区域的肿瘤细胞中。这些结果表明，ERBB2和ERBB3的过表达与腺样囊性癌的肿瘤分化和浸润有关。
