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Characterization of the transferrin-iron uptake system in Neisseria meningitidis.脑膜炎奈瑟菌中转铁蛋白 - 铁摄取系统的特性研究
FEMS Microbiol Lett. 1993 Sep 1;112(2):159-65. doi: 10.1111/j.1574-6968.1993.tb06442.x.
2
Cloning and characterization of Neisseria meningitidis genes encoding the transferrin-binding proteins Tbp1 and Tbp2.编码转铁蛋白结合蛋白Tbp1和Tbp2的脑膜炎奈瑟菌基因的克隆与鉴定
Gene. 1993 Aug 16;130(1):73-80. doi: 10.1016/0378-1119(93)90348-7.
3
A functional tonB gene is required for both utilization of heme and virulence expression by Haemophilus influenzae type b.功能性tonB基因是b型流感嗜血杆菌利用血红素和表达毒力所必需的。
Infect Immun. 1994 Jun;62(6):2470-7. doi: 10.1128/iai.62.6.2470-2477.1994.
4
Cloning and sequence analysis of the fur gene encoding an iron-regulatory protein of Neisseria meningitidis.脑膜炎奈瑟菌铁调节蛋白fur基因的克隆与序列分析
Gene. 1994 Apr 8;141(1):139-40. doi: 10.1016/0378-1119(94)90143-0.
5
In vivo human immune response to transferrin-binding protein 2 and other iron-regulated proteins of Neisseria meningitidis.人对脑膜炎奈瑟菌转铁蛋白结合蛋白2及其他铁调节蛋白的体内免疫反应。
FEMS Immunol Med Microbiol. 1994 Jan;8(1):63-8. doi: 10.1111/j.1574-695X.1994.tb00426.x.
6
Fur regulon in gram-negative bacteria. Identification and characterization of new iron-regulated Escherichia coli genes by a fur titration assay.革兰氏阴性菌中的铁摄取调节子。通过铁摄取调节蛋白（Fur）滴定法鉴定和表征新的铁调节大肠杆菌基因。
J Mol Biol. 1994 Feb 18;236(2):531-45. doi: 10.1006/jmbi.1994.1163.
7
Transferrin receptors on ruminant pathogens vary in their interaction with the C-lobe and N-lobe of ruminant transferrins.反刍动物病原体上的转铁蛋白受体与反刍动物转铁蛋白的C叶和N叶的相互作用各不相同。
Can J Microbiol. 1994 Jul;40(7):532-40. doi: 10.1139/m94-086.
8
The C-terminal sequence conservation between OmpA-related outer membrane proteins and MotB suggests a common function in both gram-positive and gram-negative bacteria, possibly in the interaction of these domains with peptidoglycan.OmpA相关外膜蛋白与MotB之间的C末端序列保守性表明，在革兰氏阳性菌和革兰氏阴性菌中存在共同功能，可能在于这些结构域与肽聚糖的相互作用。
Mol Microbiol. 1994 Apr;12(2):333-4. doi: 10.1111/j.1365-2958.1994.tb01021.x.
9
Immune responses in humans and animals to meningococcal transferrin-binding proteins: implications for vaccine design.人类和动物对脑膜炎球菌转铁蛋白结合蛋白的免疫反应：对疫苗设计的启示。
Infect Immun. 1994 Jul;62(7):2984-90. doi: 10.1128/iai.62.7.2984-2990.1994.
10
Observation of binding and polymerization of Fur repressor onto operator-containing DNA with electron and atomic force microscopes.利用电子显微镜和原子力显微镜观察Fur阻遏蛋白与含操纵基因的DNA的结合及聚合情况。
Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):11816-20. doi: 10.1073/pnas.91.25.11816.

胸膜肺炎放线杆菌转铁蛋白结合蛋白1基因的克隆、测序及表达

Cloning, sequencing and expression of the transferrin-binding protein 1 gene from Actinobacillus pleuropneumoniae.

作者信息

Daban M, Medrano A, Querol E

机构信息

Institut de Biologia Fonamental and Department de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Barcelona, Spain.

出版信息

Biochem J. 1996 Apr 1;315 ( Pt 1)(Pt 1):257-64. doi: 10.1042/bj3150257.

DOI:10.1042/bj3150257
PMID:8670116
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1217180/
Abstract

Two outer-membrane proteins are involved in the uptake of iron from transferrin by certain Gram-negative bacteria, transferrin-binding proteins 1 and 2. The gene encoding transferrin-binding protein 1 from a serotype 1 isolate of the Gram-negative pathogen Actinobacillus pleuropneumoniae was cloned, and a fragment encoding 700 amino acids of Tbp1 was expressed in Escherichia coli. We also report here sequencing of the tbpl gene and a comparison of the deduced amino acid sequence with Tbpls from related species. The predicted polypeptide product of tbpl is a 106 kDa protein with a 22-residue signal peptide.

摘要

某些革兰氏阴性菌从转铁蛋白摄取铁的过程涉及两种外膜蛋白，即转铁蛋白结合蛋白1和2。对革兰氏阴性病原体胸膜肺炎放线杆菌血清型1分离株中编码转铁蛋白结合蛋白1的基因进行了克隆，并在大肠杆菌中表达了编码Tbp1 700个氨基酸的片段。我们还在此报告了tbpl基因的测序结果以及推导的氨基酸序列与相关物种的Tbpls的比较。tbpl预测的多肽产物是一种106 kDa的蛋白质，带有一个22个残基的信号肽。