Hibberts N A, Messenger A G, Randall V A
Department of Biomedical Sciences, University of Bradford, United Kingdom.
Biochem Biophys Res Commun. 1996 May 15;222(2):401-5. doi: 10.1006/bbrc.1996.0756.
As stem cell factor (SCF) and its receptor, c-kit, are involved in hair pigmentation, SCF is probably produced in the skin, possibly by the regulatory follicular dermal papilla. Since androgens often alter the type and color of hair, probably via the dermal papilla, they may regulate its SCF production. SCF produced by beard and non-balding scalp dermal papilla cells in the presence, or absence, of 10nM testosterone was assayed by ELISA. After 24 h, beard cells produced significantly (p = 0.001) more SCF than scalp cells, while beard and scalp fibroblasts secreted significantly (p = 0.04) less SCF. Testosterone in vitro had no effect on SCF secretion. These results support the hypotheses that the dermal papilla is a local source of SCF in hair follicles and that androgens would alter SCF production only at specific points of the hair cycle.
由于干细胞因子（SCF）及其受体c-kit参与毛发色素沉着，SCF可能在皮肤中产生，可能由调节性毛囊真皮乳头产生。由于雄激素通常可能通过真皮乳头改变毛发的类型和颜色，它们可能调节其SCF的产生。通过酶联免疫吸附测定法（ELISA）检测在存在或不存在10nM睾酮的情况下，胡须和非秃发头皮真皮乳头细胞产生的SCF。24小时后，胡须细胞产生的SCF明显（p = 0.001）多于头皮细胞，而胡须和头皮成纤维细胞分泌的SCF明显（p = 0.04）较少。体外睾酮对SCF分泌没有影响。这些结果支持以下假设：真皮乳头是毛囊中SCF的局部来源，并且雄激素仅在毛发周期的特定点改变SCF的产生。
