Soto-Otero R, Riguera-Vega R, Méndez-Alvarez E, Sánchez-Sellero I, López-Rivadulla Lamas M
Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universidad de Santiago de Compostela, Spain.
Biochem Biophys Res Commun. 1996 May 15;222(2):607-11. doi: 10.1006/bbrc.1996.0791.
Tetrahydroisoquinoline (TIQ), a presumed proneutrotoxin linked with Parkinson's disease (PD), was found to interact with some components of cigarette smoke to give N-(cyanomethyl)-TIQ (CMTIQ), N-(1'-cyanoethyl)-TIQ (CETIQ), N-(1'-cyanopropyl)-TIQ (CPTIQ), N-(1'-cyanobutyl)-TIQ (CBTIQ), and 1-cyano-TIQ (1CTIQ). The in vitro formation of these compounds under physiological conditions occurs rapidly and with a high yield. Significant differences in the recovery of the different compounds were obtained when the data obtained from Burley tobacco were compared to those obtained from Bright tobacco. Following chronic administration of TIQ and a solution of cigarette smoke to rats, the presence of some of these compounds was also detected in the brain.
四氢异喹啉（TIQ）是一种被认为与帕金森病（PD）相关的潜在原毒素，它被发现可与香烟烟雾的某些成分相互作用，生成N-（氰甲基）-TIQ（CMTIQ）、N-（1'-氰乙基）-TIQ（CETIQ）、N-（1'-氰丙基）-TIQ（CPTIQ）、N-（1'-氰丁基）-TIQ（CBTIQ）和1-氰基-TIQ（1CTIQ）。这些化合物在生理条件下的体外形成迅速且产率高。将白肋烟所得数据与烤烟所得数据进行比较时，不同化合物的回收率存在显著差异。给大鼠长期施用TIQ和香烟烟雾溶液后，在其大脑中也检测到了其中一些化合物的存在。
