Makino Y, Ohta S, Tachikawa O, Hirobe M
Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Life Sci. 1988;43(4):373-8. doi: 10.1016/0024-3205(88)90115-4.
This is the first report confirming the presence of 1,2,3,4-tetrahydroisoquinoline (TIQ) and 1-methyl-1,2,3,4-tetrahydroisoquinoline(1MeTIQ) in a number of foods with a high 2-phenylethylamine content. These compounds were determined by gas chromatography-mass spectrometry. This study also confirmed that 1MeTIQ and TIQ can cross the blood-brain barrier in rat. Thus, these compounds, suspected to have relation to parkinson's disease, may accumulate in the brain from food sources.
这是第一份证实多种富含2-苯乙胺的食物中存在1,2,3,4-四氢异喹啉（TIQ）和1-甲基-1,2,3,4-四氢异喹啉（1MeTIQ）的报告。这些化合物通过气相色谱-质谱法测定。该研究还证实1MeTIQ和TIQ能够穿过大鼠的血脑屏障。因此，这些疑似与帕金森病有关的化合物可能从食物来源在大脑中蓄积。
