McKendry R J, Huebsch L, Leclair B
Ottawa General Hospital, Ontario, Canada.
Arthritis Rheum. 1996 Jul;39(7):1246-53. doi: 10.1002/art.1780390727.
The progression of rheumatoid arthritis (RA) is documented in a patient receiving a sex-mismatched, allogeneic bone marrow transplant (BMT) for gold-induced marrow aplasia. DNA typing confirmed a high probability of a full donor engraftment (complete chimerism). Although the RA was in complete remission 2 years post-BMT, clinical, laboratory, histologic, and radiologic evidence of the recurrence of synovitis from 3-13 years post-BMT is presented. Implications of these observations for theories of the pathogenesis of RA and the future of immunotherapies are discussed.
一名因金制剂所致骨髓再生障碍而接受性别不匹配的同种异体骨髓移植（BMT）的患者，其类风湿关节炎（RA）病情进展得到记录。DNA分型证实完全供体植入（完全嵌合体）的可能性很高。尽管类风湿关节炎在骨髓移植后2年完全缓解，但本文呈现了骨髓移植后3至13年滑膜炎复发的临床、实验室、组织学和放射学证据。本文还讨论了这些观察结果对类风湿关节炎发病机制理论及免疫治疗未来发展的意义。
