Baldwin J L, Storb R, Thomas E D, Mannik M
Arthritis Rheum. 1977 Jun;20(5):1043-8. doi: 10.1002/art.1780200502.
Aplastic anemia is a rare but usually fatal complication of gold salt therapy for rheumatoid arthritis. This report describes 3 patients who developed aplastic anemia while receiving gold salts, and a fourth patient who developed aplastic anemia after receiving gold and then cytotoxic agents. These patients failed to respond to conventional therapy for aplastic anemia and subsequently received bone marrow transplants from HLA-matched siblings. Engraftment occurred in all 4 patients. One patient is alive 2 years after transplantation, and 3 patients died of complications following transplantation.
再生障碍性贫血是类风湿关节炎金盐治疗中一种罕见但通常致命的并发症。本报告描述了3例在接受金盐治疗时发生再生障碍性贫血的患者，以及第4例在接受金盐治疗后又接受细胞毒性药物治疗后发生再生障碍性贫血的患者。这些患者对再生障碍性贫血的传统治疗无反应，随后接受了来自人类白细胞抗原（HLA）匹配同胞的骨髓移植。所有4例患者均实现了植入。1例患者在移植后2年存活，3例患者在移植后死于并发症。
