Kesner R P, Hunt M E, Williams J M, Long J M
Department of Psychology, University of Utah, Salt Lake City 84112, USA.
Cereb Cortex. 1996 Mar-Apr;6(2):311-8. doi: 10.1093/cercor/6.2.311.
In the first experiment, rats were trained on a working memory task for a spatial response (right-left turn) information using a delayed matching-to-sample procedure. Following lesions of the medial prefrontal cortex (MPF), which includes anterior cingulate and medial precentral cortex, there was a profound working memory deficit even at the shortest delay. In the second experiment, rats were trained on a working memory task for spatial location information using a delayed matching-to-sample procedure. Following lesions of the MPF, there was only a mild working memory deficit, whereas following dorsal hippocampal lesions there was a profound working memory deficit even at the shortest delay. In the third experiment, rats were trained on a working memory task for visual object information using a delayed nonmatching-to-sample procedure. Following lesions of the MPF, there were no working memory deficits, whereas following lesions of the prelimbic and infralimbic cortex there was a profound working memory deficit even at the shortest delay. The results suggest that different neural subregions of the prefrontal cortex mediate working memory for specific attribute information.
在第一个实验中，使用延迟样本匹配程序训练大鼠完成一项关于空间反应（左右转向）信息的工作记忆任务。在内侧前额叶皮质（MPF，包括前扣带回和中央前内侧皮质）受损后，即使在最短延迟情况下，大鼠也出现了严重的工作记忆缺陷。在第二个实验中，使用延迟样本匹配程序训练大鼠完成一项关于空间位置信息的工作记忆任务。MPF受损后，仅出现轻微的工作记忆缺陷，而背侧海马体受损后，即使在最短延迟情况下，也出现了严重的工作记忆缺陷。在第三个实验中，使用延迟非匹配样本程序训练大鼠完成一项关于视觉物体信息的工作记忆任务。MPF受损后，未出现工作记忆缺陷，而边缘前皮质和边缘下皮质受损后，即使在最短延迟情况下，也出现了严重的工作记忆缺陷。结果表明，前额叶皮质的不同神经亚区域介导特定属性信息的工作记忆。
