Tennissen A M, McCutcheon N B
Department of Psychology, College of Saint Rose, Albany, NY 12203, USA.
Chem Senses. 1996 Apr;21(2):113-20. doi: 10.1093/chemse/21.2.113.
Suppression of the saltiness of NaCl solutions by amiloride, a sodium channel blocker, has previously been reported a number of times in humans. This suppression was seen with techniques that involved stimulation of small areas of the tongue. It was not certain, however, whether amiloride would suppress saltiness with stimulation of a much larger area of the tongue; one published study, in fact, found negative results with whole mouth stimulation. For this study, eight subjects dipped a large part of the anterior portion of the tongue into a 10-ml sample of NaCl solution, or a NaCl and amiloride solution, and reported its magnitude of saltiness intensity. The results show that amiloride suppressed the saltiness of NaCl when a large area of the anterior tongue was stimulated. Consistent with previous studies, there was individual variability across subjects in this suppressive effect of amiloride. This study also used this method to test the effects of amiloride on the sourness of citric acid, which was not expected to be affected. No suppression of sourness was seen with amiloride.
钠通道阻滞剂氨氯吡咪对氯化钠溶液咸味的抑制作用此前在人体中已有多次报道。这种抑制作用在涉及刺激小面积舌部的技术中可见。然而，尚不确定氨氯吡咪在刺激更大面积舌部时是否会抑制咸味；事实上，一项已发表的研究发现全口刺激时结果为阴性。在本研究中，8名受试者将舌前部的大部分浸入10毫升氯化钠溶液样本或氯化钠与氨氯吡咪混合溶液中，并报告其咸味强度大小。结果表明，当大面积刺激舌前部时，氨氯吡咪会抑制氯化钠的咸味。与之前的研究一致，氨氯吡咪的这种抑制作用在不同受试者之间存在个体差异。本研究还使用该方法测试了氨氯吡咪对柠檬酸酸味的影响，预计其不会受到影响。未观察到氨氯吡咪对酸味的抑制作用。
