Christophe J L, van Ypersele de Strihou C, Pirson Y
Service de Nephrologie, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
Nephrol Dial Transplant. 1996 Jul;11(7):1271-6.
The impact of renal and extrarenal manifestations of autosomal dominant polycystic kidney disease (ADPKD) during chronic haemodialysis (HD) has never been assessed in a paired case-control study.
Comparison of the course of 50 ADPKD patients with 50 matched control (C) patients who started chronic HD at the same time.
Follow-up averaged 48 and 39 months in the ADPKD and C groups respectively. Actuarial survival was similar in both groups. Prevalence of renal pain (36 vs 2%, P=0.0001), haematuria (36 vs 16%, P<0.03) and renal infection (16 vs 2%, P<0.04) was higher in the ADPKD than in the C group. Nephrectomy during HD was performed in six ADPKD (in 4 cases in preparation for transplantation) and in one control patient. Number of patients with coronary and heart valve complications was similar in both groups. Stroke occurred in three patients from both groups. Only two ADPKD patients experienced a single episode of pain related to liver cyst. Prevalence of severe infection was similar in the ADPKD group (36%) and the C group (28%). Number and duration of hospitalizations were similar in both groups.
The overall outcome of ADPKD patients on maintenance HD is similar to that of HD patients with other primary renal diseases. Complications related to cystic kidneys are frequent but rarely severe. Extrarenal manifestations of ADPKD have a limited clinical impact in this short-term study.
在一项配对病例对照研究中，从未评估过常染色体显性多囊肾病（ADPKD）的肾脏和肾外表现对慢性血液透析（HD）的影响。
比较50例ADPKD患者与50例同时开始慢性HD的匹配对照（C）患者的病程。
ADPKD组和C组的随访时间分别平均为48个月和39个月。两组的精算生存率相似。ADPKD组肾痛（36%对2%，P=0.0001）、血尿（36%对16%，P<0.03）和肾脏感染（16%对2%，P<0.04）的发生率高于C组。HD期间，6例ADPKD患者（4例为移植做准备）和1例对照患者接受了肾切除术。两组冠状动脉和心脏瓣膜并发症患者数量相似。两组均有3例患者发生中风。只有2例ADPKD患者经历过一次与肝囊肿相关的疼痛发作。ADPKD组（36%）和C组（28%）严重感染的发生率相似。两组的住院次数和住院时间相似。
维持性HD的ADPKD患者的总体结局与其他原发性肾病的HD患者相似。与多囊肾相关的并发症很常见，但很少严重。在这项短期研究中，ADPKD的肾外表现对临床的影响有限。
