与BUF/Mna大鼠胸腺肿大相关的两个基因座Ten-1和Ten-2的定位

Mapping of two genetic loci, Ten-1 and Ten-2, associated with thymus enlargement in BUF/Mna rats.

作者信息

Murakumo Y, Takahashi M, Sharma N, Arakawa A, Saito M, Amo H, Matsuyama M

机构信息

Department of Pathology, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466, Japan.

出版信息

Mamm Genome. 1996 Jul;7(7):505-8. doi: 10.1007/s003359900152.

DOI:10.1007/s003359900152

PMID:8672128

Abstract

The thymoma-prone BUF/Mna rat is a useful model for human thymoma. Thymoma develops spontaneously in these rats at an incidence of nearly 100%. At pre-thymoma age, BUF/Mna rats have extremely large thymuses when compared with those of rats of the other strains, suggesting the presence of genes that regulate the thymus enlargement. We performed linkage study to identify the genetic loci associated with thymus enlargement in {(WKY/NCrj x BUF/Mna) F1 x BUF/Mna} backcross rats. Linkage study showed the significant associations between thymus size and markers on Chromosomes (Chrs) 1 and 13, suggesting the presence of two genes, Ten-1 and Ten-2, which regulate the thymus enlargement. Ten-1 was located between myosin light chain, muscle 2 (MYL2) and D1Mgh11 loci on Chr 1, and Ten-2 was located between synaptotagmin II (SYT2) and D13N2 loci on Chr 13.

摘要

易患胸腺瘤的BUF/Mna大鼠是人类胸腺瘤的有用模型。这些大鼠中胸腺瘤自发发生，发生率近100%。在胸腺瘤前期，与其他品系的大鼠相比，BUF/Mna大鼠的胸腺极大，提示存在调控胸腺增大的基因。我们在{（WKY/NCrj×BUF/Mna）F1×BUF/Mna}回交大鼠中进行连锁研究，以鉴定与胸腺增大相关的基因座。连锁研究显示胸腺大小与1号和13号染色体（Chrs）上的标记之间存在显著关联，提示存在两个调控胸腺增大的基因Ten-1和Ten-2。Ten-1位于1号染色体上的肌球蛋白轻链、肌肉2（MYL2）和D1Mgh11基因座之间，Ten-2位于13号染色体上的突触结合蛋白II（SYT2）和D13N2基因座之间。