BUF/Mna大鼠中与胸腺大小增大相关的基因座的染色体定位。
Chromosomal mapping of genetic locus associated with thymus-size enlargement in BUF/Mna rats.
作者信息
Murakumo Y, Takahashi M, Arakawa A, Saito M, Amo H, Katoh H, Matsuyama M
机构信息
Department of Pathology, Nagoya University School of Medicine.
出版信息
Jpn J Cancer Res. 1993 Aug;84(8):838-40. doi: 10.1111/j.1349-7006.1993.tb02054.x.
The thymoma-prone rat of the BUF/Mna strain is a useful model for human thymoma. In this strain thymoma development is regulated by a single autosomal susceptible gene, Tsr-1. At pre-thymoma age, BUF/Mna rats have extremely large thymuses, when compared to those of other strains of rats. Genetic studies in crosses between BUF/Mna rats with large thymuses and WKY/NCrj rats with small thymuses suggested the presence of a major autosomal gene, Ten-1, which contributes to thymus enlargement in a backcross population. Linkage studies between Ten-1 and microsatellite markers in backcross rats of (WKY/NCrj x BUF/Mna)F1 x BUF/Mna have led to the localization of Ten-1 in chromosome 1. This result may provide an approach to clone Tsr-1, which could be allelic to Ten-1.
BUF/Mna品系的胸腺瘤易感大鼠是人类胸腺瘤的有用模型。在该品系中，胸腺瘤的发生受单个常染色体易感基因Tsr-1调控。在胸腺瘤前期，与其他品系的大鼠相比，BUF/Mna大鼠具有极其庞大的胸腺。对胸腺大的BUF/Mna大鼠和胸腺小的WKY/NCrj大鼠进行杂交的遗传学研究表明，存在一个主要的常染色体基因Ten-1，它在回交群体中导致胸腺增大。在(WKY/NCrj×BUF/Mna)F1×BUF/Mna回交大鼠中对Ten-1和微卫星标记进行连锁研究，已将Ten-1定位到1号染色体上。这一结果可能为克隆Tsr-1提供一种方法，Tsr-1可能与Ten-1是等位基因。
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