[外阴癌的近期预后因素：组织学、免疫组织化学及流式细胞术研究]
[Recent prognostic factors in vulvar carcinoma: histological, immunohistochemical and flow cytometry studies].
作者信息
Weikel W, Beck T, Moll R, Brumm C, Knapstein P G
机构信息
Universitätsfrauenklinik Mainz.
出版信息
Gynakol Geburtshilfliche Rundsch. 1995;35 Suppl 1:11-4. doi: 10.1159/000272556.
OBJECTIVES
Are newer histologic investigations helpful in the evaluation of the prognosis of vulvar carcinoma?
METHODS
147 primary squamous cell carcinomas of the vulva were examined for overall- and disease-free survival (mean observation 59.6 months).
RESULTS
A significance in prognosis was found for FIGO-stage, a new-created histologic grade, p53- and vimentin-expression and amount of T-lymphocytes in tumoral stroma. Unfavourable prognosis was detected for tumors with elevated growth fraction, high proliferating cell-compartment (S + G2 + M) and increased cytokeratin-8-expression.
CONCLUSIONS
These investigations are able to describe the malignant potential of a vulvar carcinoma and should therefore influence the decision for a modified radical therapy.
目的
更新的组织学研究对外阴癌预后评估有帮助吗？
方法
对147例原发性外阴鳞状细胞癌进行总生存期和无病生存期检查（平均观察期59.6个月）。
结果
发现国际妇产科联盟（FIGO）分期、新创建的组织学分级、p53和波形蛋白表达以及肿瘤间质中T淋巴细胞数量对预后有显著意义。生长分数升高、增殖细胞区室（S + G2 + M）高和细胞角蛋白8表达增加的肿瘤预后不良。
结论
这些研究能够描述外阴癌的恶性潜能，因此应影响改良根治性治疗的决策。
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