Sohn C, Bastert G
Sektion für pränatale und gynäkologische Ultraschalldiagnostik und Therapie, Universitätsfrauenklinik Heidelberg.
Gynakol Geburtshilfliche Rundsch. 1995;35 Suppl 1:98-102. doi: 10.1159/000272573.
The aim of the present study was to find a possible relationship between biological behavior of breast cancer and sonographically detectable blood flow.
157 patients with ductal invasive breast cancer were examined by means of a new sonographic procedure, the MEM (Maximum Entropy Method), able to detect considerably lower blood flow velocities than doppler sonography. In the absence of objectifyable quantification methods, findings were allotted to 3 classes, depending on the visual color information obtained. Blood flow was correlated to tumor size, lymph node and receptor status, ploidy and S-phase-fraction.
Most patients with small tumors, no lymph node metatases, positive receptors, diploid genome and low S-phase found to have low blood flow.
This close relation between established prognostic factors and results of sonographic blood flow examination with the MEM might indicate a new preoperative prognostic factor, which, however, will have to be proven by larger studies.
本研究旨在探寻乳腺癌生物学行为与超声可检测到的血流之间可能存在的关系。
采用一种新的超声检查方法——最大熵方法（MEM）对157例乳腺浸润性导管癌患者进行检查，该方法能够检测到比多普勒超声更低的血流速度。在缺乏可客观量化方法的情况下，根据所获得的视觉颜色信息，将检查结果分为3类。将血流情况与肿瘤大小、淋巴结及受体状态、倍体和S期分数进行关联分析。
大多数肿瘤较小、无淋巴结转移、受体阳性、基因组为二倍体且S期分数较低的患者，其血流也较低。
既定的预后因素与采用MEM进行超声血流检查结果之间的这种密切关系，可能预示着一种新的术前预后因素，不过，这还有待更大规模的研究加以证实。
