Belich A I, Konstantinova N N, Natsvlishvili V V, Pavlova N G, Popova N I
Vestn Ross Akad Med Nauk. 1996(3):55-61.
The natural behavior of normal and anencephalic fetuses at 20 to 41 weeks of the development was studied by ultrasound monitoring and continuous recording of heart rate (HR) and motor activity (MA), followed by processing and presentation on [symbol: see text]CM computer. The statistical characteristics of HR and MA changes in the anencephalic fetuses were corrected by the degree of CNS deficiency. The comparative study of 20 normal and 34 anencephalic fetuses showed: 1) when the spinal cord was present, stable HR (about 150 bpm) seems to be due to cardiac automatism and sharp decelerations unaccompanied by MA were recorded; 2) in fetuses with the medulla oblongata present showed a decrease in baseline HR up to 140 bpm, repeated pronounced decelerations and spontaneous single motor acts dissociated with the latter; 3) when a rudiment of the midbrain was present, some reductions in the amplitude of decelerations and manifestation of weak accelerations, cluster motor acts, brief episodes of the active state were revealed; 4) the quiet state was observed in fetuses with the cerebral cortex; 5) the rest-activity cycle formed with further differentiation of the cerebral cortex.
通过超声监测以及连续记录心率（HR）和运动活动（MA），随后在[符号：见文本]CM计算机上进行处理和呈现，研究了20至41周发育的正常胎儿和无脑儿的自然行为。无脑儿胎儿HR和MA变化的统计特征根据中枢神经系统缺陷程度进行了校正。对20例正常胎儿和34例无脑儿胎儿的比较研究表明：1）当脊髓存在时，稳定的心率（约150次/分钟）似乎归因于心脏自律性，且记录到不伴有MA的急剧减速；2）在延髓存在的胎儿中，基线心率降至140次/分钟，反复出现明显减速，且出现与减速无关的自发单次运动行为；3）当中脑雏形存在时，减速幅度有所降低，出现微弱加速、集群运动行为以及短暂的活跃状态发作；4）在有大脑皮层的胎儿中观察到安静状态；5）随着大脑皮层的进一步分化形成了静息-活动周期。
