Price C J, Wise R J, Warburton E A, Moore C J, Howard D, Patterson K, Frackowiak R S, Friston K J
Wellcome Department of Cognitive Neurology, Institute of Neurology, Queen Square, London, UK.
Brain. 1996 Jun;119 ( Pt 3):919-31. doi: 10.1093/brain/119.3.919.
The neural systems involved in hearing and repeating single words were investigated in a series of experiments using PET. Neuropsychological and psycholinguistic studies implicate the involvement of posterior and anterior left perisylvian regions (Wernicke's and Broca's areas). Although previous functional neuroimaging studies have consistently shown activation of Wernicke's area, there has been only variable implication of Broca's area. This study demonstrates that Broca's area is involved in both auditory word perception and repetition but activation is dependent on task (greater during repetition than hearing) and stimulus presentation (greater when hearing words at a slow rate). The peak of frontal activation in response to hearing words is anterior to that associated with repeating words; the former is probably located in Brodmann's area 45, the latter in Brodmann's area 44 and the adjacent precentral sulcus. As Broca's area activation is more subtle and complex than that in Wernicke's area during these tasks, the likelihood of observing it is influenced by both the study design and the image analysis technique employed. As a secondary outcome from the study, the response of bilateral auditory association cortex to 'own voice' during repetition was shown to be the same as when listening to "other voice' from a prerecorded tape.
在一系列使用正电子发射断层扫描（PET）的实验中，对参与听力和重复单个单词的神经系统进行了研究。神经心理学和心理语言学研究表明，左外侧裂周区后部和前部（韦尼克区和布洛卡区）参与其中。尽管先前的功能神经影像学研究一直显示韦尼克区有激活，但布洛卡区的参与情况却不尽相同。本研究表明，布洛卡区参与听觉单词感知和重复，但激活情况取决于任务（重复时比听力时更强烈）和刺激呈现方式（以缓慢语速听单词时更强烈）。听到单词时额叶激活的峰值位于与重复单词相关的峰值之前；前者可能位于布罗德曼45区，后者位于布罗德曼44区及相邻的中央前沟。由于在这些任务中，布洛卡区的激活比韦尼克区更微妙、更复杂，观察到它的可能性受到研究设计和所采用的图像分析技术的影响。作为该研究的次要结果，研究表明双侧听觉联合皮层在重复过程中对“自己的声音”的反应与听预先录制磁带中的“他人声音”时相同。
