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Selective control of cytosolic glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase mRNA stability by selenium supply.

作者信息

Bermano G, Arthur J R, Hesketh J E

机构信息

Division of Biochemical Sciences, Rowett Research Institute, Bucksburn, Aberdeen, UK.

出版信息

FEBS Lett. 1996 Jun 3;387(2-3):157-60. doi: 10.1016/0014-5793(96)00493-0.

DOI:10.1016/0014-5793(96)00493-0
PMID:8674540
Abstract

Selenium depletion of H4 hepatoma cells reduced cytosolic glutathione peroxidase (cGSH-Px) mRNA abundance but had no effect on phospholipid hydroperoxide glutathione peroxidase (PHGSH-Px) mRNA abundance. Actinomycin D chase experiments showed that selenium depletion had no effect on the stability of PHGSH-Px mRNA but decreased the stability of cGSH-Px mRNA. In Se-replete cells puromycin decreased the stability of both cGSH-Px and PHGSH-Px mRNAs. The results suggest that when selenium supply is limiting PHGSH-Px mRNA translation is maintained more than that of cGSH-Px mRNA, and thus more cGSH-Px mRNA is released from polysomes and degraded.

摘要

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