非甾体抗炎药会诱导T淋巴细胞中的姐妹染色单体交换吗？

Do non-steroidal anti-inflammatory drugs induce sister chromatid exchanges in T lymphocytes?

作者信息

Ozkul Y, Erenmemisoglu A, Ekecik A, Saatci C, Ozdamar S, Demirtas H

机构信息

Department of Medical Biology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.

出版信息

J Int Med Res. 1996 Jan-Feb;24(1):84-7. doi: 10.1177/030006059602400110.

DOI:10.1177/030006059602400110

PMID:8674803

Abstract

The genetic toxicity of non-steroidal anti-inflammatory drugs was investigated using the sister chromatid exchange technique in cultured human lymphocytes. A total of 48 patients were treated with non-steroidal anti-inflammatory drugs (ibuprofen, ketoprofen, naproxen, indomethacin, diclofenac or acetylsalicylic acid) for 2 weeks. The average numbers of sister chromatid exchanges in cultured lymphocytes from the patients, before and after treatment with these drugs, did not differ significantly (P > 0.05). These results indicate that treatment with non-steroidal anti-inflammatory drugs for 2 weeks does not induce sister chromatid exchanges in T lymphocytes.

摘要

采用姐妹染色单体交换技术，在培养的人淋巴细胞中研究了非甾体抗炎药的遗传毒性。共有48例患者接受了非甾体抗炎药（布洛芬、酮洛芬、萘普生、吲哚美辛、双氯芬酸或乙酰水杨酸）治疗，为期2周。这些药物治疗前后，患者培养淋巴细胞中姐妹染色单体交换的平均数无显著差异（P>0.05）。这些结果表明，非甾体抗炎药治疗2周不会诱导T淋巴细胞发生姐妹染色单体交换。