Philipose B, Singh R, Khan K A, Giri A K
Indian Institute of Chemical Biology, Jadavpur, Calcutta, India.
Mutat Res. 1997 Sep 18;393(1-2):123-31. doi: 10.1016/s1383-5718(97)00095-8.
The mutagenicity of three propionic acid derivatives, namely ibuprofen, ketoprofen and naproxen, was tested in the Ames mutagenicity assay (in strains TA97a, TA100 and TA102) and in vivo genotoxicity was tested by sister chromatid exchange (SCE) in bone marrow cells of mice. These are the anti-inflammatory drugs frequently used in different parts of the world. Mutagenicity results showed no mutagenic effects in strains TA97a, TA100 and TA102 for all three drugs. Results of in vivo SCE assays indicate that these three drugs are weakly genoxic in bone marrow cells of mice. This is the first report of the Ames mutagenicity assay for ketoprofen and in vivo SCE assay for three drugs.
在艾姆斯致突变试验（使用TA97a、TA100和TA102菌株）中测试了三种丙酸衍生物，即布洛芬、酮洛芬和萘普生的致突变性，并通过小鼠骨髓细胞中的姐妹染色单体交换（SCE）试验测试了其体内遗传毒性。这些是在世界不同地区经常使用的抗炎药。致突变性结果表明，这三种药物对TA97a、TA100和TA102菌株均无致突变作用。体内SCE试验结果表明，这三种药物在小鼠骨髓细胞中具有弱遗传毒性。这是关于酮洛芬的艾姆斯致突变试验以及这三种药物的体内SCE试验的首次报告。
