Investigations of the influence of nonsteroidal antirheumatic drugs on the rates of sister-chromatid exchange.

For detection of possible damage to genetic material due to nonsteroidal antirheumatic drugs, a technique was used to determine sister-chromatid exchange rates. The SCE rates before and after therapeutic application of several nonsteroidal antirheumatic drugs (diclofenac, flurbiprofen, ibuprofen, indomethacin, isoxicam, ketoprofen, piroxicam, pirprofen, tiaprofenic acid) were determined in human lymphocytes in vivo. The cytogenetic investigations of these nonsteroidal antirheumatic agents did not reveal any genetic effects during a treatment period of two weeks.