Savides T J, See J A, Jensen D M, Jutabha R, Machicado G A, Hirabayashi K
Department of Medicine, UCLA Center for Health Sciences, USA.
Gastrointest Endosc. 1995 Dec;42(6):573-8. doi: 10.1016/s0016-5107(95)70013-7.
Monopolar hot biopsy forceps (HBF), bipolar HBF, and cold biopsy forceps (CBF) followed by bipolar electrocoagulation are used clinically to simultaneously perform a biopsy and coagulate diminutive colon polyps and angiomata. Our purpose was to conduct a randomized, controlled study to evaluate the safety of these different techniques in the canine right colon.
After right colotomy in 8 mongrel dogs, colonic mucosa was grasped en face, tented, and biopsy performed in randomized order. The dogs were sacrificed after nine days and the biopsy sites were identified and histologically examined.
Monopolar HBF caused an overall mean rate of acute serosal whitening of 29% compared with 0% for bipolar HBF and CBF and 6% for CBF/bipolar probe. Histologically confirmed transmural injury 9 days after biopsy occurred in 44% of monopolar HBF compared with 5% of bipolar HBF, 0% of CBF, and 50% of CBF/bipolar probe.
Monopolar HBF had significantly higher rates of acute serosal whitening and histologic transmural damage than bipolar HBF or cold biopsy alone. On the basis of these results, monopolar HBF should be avoided for coagulation of small or flat right colon lesions such as diminutive polyps or angiomata.
单极热活检钳（HBF）、双极HBF和冷活检钳（CBF）随后进行双极电凝，临床上用于同时进行活检并凝固微小的结肠息肉和血管瘤。我们的目的是进行一项随机对照研究，以评估这些不同技术在犬右结肠中的安全性。
对8只杂种犬进行右半结肠切开术后，将结肠黏膜全层提起、呈帐篷状，然后按随机顺序进行活检。9天后处死犬只，确定活检部位并进行组织学检查。
单极HBF导致急性浆膜变白的总体平均发生率为29%，而双极HBF和CBF为0%，CBF/双极探头为6%。活检9天后，组织学证实的透壁损伤在单极HBF组中发生率为44%，双极HBF组为5%，CBF组为0%，CBF/双极探头组为50%。
单极HBF的急性浆膜变白率和组织学透壁损伤率明显高于双极HBF或单纯冷活检。基于这些结果，对于小的或扁平的右结肠病变，如微小息肉或血管瘤的凝固，应避免使用单极HBF。
